tag:blogger.com,1999:blog-2642852074030612286.comments2016-03-26T13:35:48.097-04:00My Lab and MeDavid Le Borgnehttp://www.blogger.com/profile/15237539905704151219noreply@blogger.comBlogger16125tag:blogger.com,1999:blog-2642852074030612286.post-91132196322212325452016-03-26T13:35:48.097-04:002016-03-26T13:35:48.097-04:00Update: Added price comparison between the two rou...Update: Added price comparison between the two routes.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-52422567801742315682016-03-26T13:34:47.889-04:002016-03-26T13:34:47.889-04:00Update: Added price comparison between the two rou...Update: Added price comparison between the two routes.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-69047451462454035542016-03-22T17:35:38.762-04:002016-03-22T17:35:38.762-04:00Update: Added an optimized alternate route for the...Update: Added an optimized alternate route for the cyclopropyl moiety, shortening the route by 2 steps with a Friedel&Craft on benzodioxole derivative.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-39433169003427686322016-03-22T17:25:09.745-04:002016-03-22T17:25:09.745-04:00Update: Added an optimized alternate route for the...Update: Added an optimized alternate route for the cyclopropyl moiety, shortening the route by 2 steps with a Friedel&Craft on benzodioxole derivative. David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-33493485248390289542016-03-07T12:18:38.282-05:002016-03-07T12:18:38.282-05:00Alternate route part IIIa convergence: Azirine pre...Alternate route part IIIa convergence: Azirine preparation and Pyrazine synthesis is online.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-18809441941400013272016-02-27T10:18:24.811-05:002016-02-27T10:18:24.811-05:00Update: Added explanations of the possible side re...Update: Added explanations of the possible side reaction in Neber Rearrangement.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-50221593984869664812016-02-25T09:46:22.039-05:002016-02-25T09:46:22.039-05:00Update: Added optimization proposal for the sequen...Update: Added optimization proposal for the sequence oximation-tosylation-Neber rearrangement.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-79003127276710322612016-02-23T17:56:36.903-05:002016-02-23T17:56:36.903-05:00Update: Added cyanide destruction treatment before...Update: Added cyanide destruction treatment before oxidation of alcohol.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-49344512801635677242016-02-21T11:11:21.712-05:002016-02-21T11:11:21.712-05:00Alternate route part II: sulfonyloxime (19) prepar...Alternate route part II: sulfonyloxime (19) preparation is online.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-33329208522857120682015-11-18T10:18:15.768-05:002015-11-18T10:18:15.768-05:00Alternate route Part I: Sulfonyloxime (13) prepara...Alternate route Part I: Sulfonyloxime (13) preparation is online.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-48259450279056166222015-11-17T10:04:41.978-05:002015-11-17T10:04:41.978-05:00If some have this reference: Iron Catalysis in Org...If some have this reference: Iron Catalysis in Organic Synthesis, Ingmar Bauer and Hans-Joachim Knölker*, Chem. Rev., 2015, 115 (9), pp 3170–3387, (DOI http://dx.doi.org/10.1021/cr500425u), please contact me through comment on this page or LinkedIn, i have no access to this publication, and the content seems to be VERY interesting, thank you per advance.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-44683064122580306272015-11-03T20:11:39.123-05:002015-11-03T20:11:39.123-05:00Update: Added the route published by Vertex and im...Update: Added the route published by Vertex and improved the readabilityDavid Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-78924494715361985372015-10-27T17:52:27.772-04:002015-10-27T17:52:27.772-04:00Update: I have finally found a patent describing t...Update: I have finally found a patent describing the route used: CA2796642A1 (http://www.google.is/patents/CA2796642A1?cl=en)<br /><br />Honestly, about the indole route, i prefer mine.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-23392900011760434382015-10-27T17:51:55.159-04:002015-10-27T17:51:55.159-04:00Update: I have finally found a patent describing t...Update: I have finally found a patent describing the route used: CA2796642A1 (http://www.google.is/patents/CA2796642A1?cl=en)<br /><br />Honestly, about the indole route, i prefer mine.David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-28617556908667098102015-10-24T11:55:44.228-04:002015-10-24T11:55:44.228-04:00Update about (14) in the details : add "Also,...Update about (14) in the details : add "Also, the haloalkane from the exchange must be removed before the cross-coupling reaction by a distillation at a reduced pressure (if the stabilized Grignard is unstable above room temp), and at a constant volume with a co-solvent or the reaction solvent."David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.comtag:blogger.com,1999:blog-2642852074030612286.post-76457524743255942872015-10-24T11:53:07.997-04:002015-10-24T11:53:07.997-04:00Update about (14) : add "Also, the haloalkane...Update about (14) : add "Also, the haloalkane from the exchange must be removed before the cross-coupling reaction by a distillation at a reduced pressure (if the stabilized Grignard is unstable above room temp), and at a constant volume with a co-solvent or the reaction solvent."David Le Borgnehttps://www.blogger.com/profile/15237539905704151219noreply@blogger.com